Jimmy Robertson.

Louisville running back Isaac Brown (1) runs downfield against Virginia Tech during the first half of an NCAA college football game, Saturday, Nov. 1, 2025, in Blacksburg, Va. (AP Photo/Robert Simmons)

Isaac Brown and Keyjuan Brown help No. 16 Louisville rush past Virginia Tech in 28-16 victory

Isaac Brown rushed for 130 yards and a touchdown before leaving late with a leg injury and Keyjuan Brown scored twice in the second half to lift No. 16 Louisville to a 28-16 victory over Virginia Tech. Miller Moss added a touchdown pass for the Cardinals, who rallied Saturday from a 16-7 halftime deficit to win their third straight game. Virginia Tech was led by Kyron Drones, who rushed for 85 yards and a touchdown and also threw for a score. But the Hokies were shut out in the second half and amassed less than 100 yards.

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