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Gary Sanchez homered and drove in four runs, Ramón Laureano scored four times and the Baltimore Orioles stormed back from an early six-run deficit to rout the Tampa Bay Rays 22-8. The Orioles were on the wrong end of a similar comeback against Tampa Bay just nine days earlier, when the Rays rallied from down 8-0 to beat Baltimore 12-8. Tampa Bay opened the scoring with six runs in the second. Jonathan Aranda, Josh Lowe and Brandon Lowe all homered in that inning, but Sanchez, Jackson Holliday, Gunnar Henderson and Coby Mayo went deep for the Orioles.

Brandon Lowe hit a tying two-run homer in the fifth inning and the Tampa Bay Rays overcame an eight-run deficit to beat the Baltimore Orioles 12-8 on Wednesday night in the largest comeback in the majors this season. Junior Camerino had four hits and two RBIs to help Tampa Bay match the biggest comeback in franchise history. The Rays also rallied from eight down in a 10-8 victory over the Angels on Aug. 18, 2012, and in a 10-9 win over Toronto on July 25, 2009. The Orioles last gave away an eight-run lead on April 28, 2017, in a 14-11 loss to the New York Yankees. Baltimore had an eight-run second inning.