Greg Iles, Mississippi author of ‘Natchez Burning’ trilogy, dies of cancer at 65
August 16, 2025
Mississippi author Greg Iles has died at 65. His literary agent Dan Conaway said Iles died Friday after a decades-long battle with the blood cancer multiple myeloma. Initially diagnosed with the incurable condition in 1996, he kept his illness private until completing his final novel, “Southern Man,” which was published in 2024. Iles was born in Germany but moved to Natchez, Mississippi, with his family when he was just 3 years old and developed a deep connection with the region. Many of his stories are set in Mississippi, including the “Natchez Burning” trilogy, historical fiction suspense novels exploring race and class in the 1960s Jim Crow South.