49ers nick bosa.

San Francisco 49ers defensive end Nick Bosa walks off the field during the first half of an NFL football game against the Arizona Cardinals, Sunday, Sept. 21, 2025, in Santa Clara, Calif. (AP Photo/Godofredo A. Vásquez)

49ers star defensive end Nick Bosa is out for the season with a torn ACL, AP source says

San Francisco star defensive end Nick Bosa tore the ACL in his right knee and will miss the rest of the season. Bosa hurt his knee in the first half of a win over Arizona on Sunday and didn’t return to the game. Bosa gave a thumbs-down after the injury but initial tests did not show a torn ACL. Coach Kyle Shanahan said after the game that more tests would be needed to determine the severity of the injury. A person familiar with the situation said on condition of anonymity because an announcement hadn’t been made that those tests showed that Bosa had torn his ACL and his season was done.

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San Francisco 49ers defensive end Nick Bosa walks off the field during the first half of an NFL football game against the Arizona Cardinals, Sunday, Sept. 21, 2025, in Santa Clara, Calif. (AP Photo/Godofredo A. Vásquez)

49ers’ Nick Bosa exits win vs. Cardinals with knee injury, gives thumbs-down to crowd

San Francisco 49ers star Nick Bosa left the win against the Arizona Cardinals with a knee injury. He exited the field favoring his right leg after a third-down pass rush in the first quarter. He went to the medical tent and later to the locker room. Bosa was ruled out at halftime. San Francisco rookie Mykel Williams also left with a wrist injury but returned quickly. Bosa, the 2022 AP NFL Defensive Player of the Year, has been crucial for the 49ers. The team has been missing several key players because of injuries, including George Kittle and Brandon Aiyuk.

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